Multiparametrical diffusion weighted imaging for the detection of anaplastic transformation of low-grade gliomas

Methods The study was approved by the local ethics committee. Forty-seven patients with histopathologically proven lowgrade glioma II° were included, 28 were stable and 19 patients had post-surgical anaplastic transformation. All patients underwent pre-operative MRI, surgery and subsequent post-operative MRI follow-ups at 1.5T including T1w, T2w sequences and a DTI-protocol. The scalar indices AD, MD and RD were calculated voxel-byvoxel for all patients from the tensor eigenvalues and the minimum value within a gross tumour segmentation was extracted using MITK-Diffusion, respectively.